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Therapeutic counseling or cognitive behavioral therapy addresses any weight-loss-related anxiety while you stabilize on semaglutide

Reduced fertility in female mice lacking copper-zinc superoxide dismutase

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Watch for dark urine, headache, dizziness, or fatigue as dehydration signs

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If the headaches are part of the body adjusting to the medication, they may persist intermittently for the first couple weeks, particularly after dose increases. In general, though, most headaches are temporary and tend to resolve within a few hours to a couple of days, he adds